Efficient image registration using fast principal component analysis

Incorporating spatial features with mutual information (MI) has demonstrated superior image registration performance compared with traditional MI-based methods, particularly in the presence of noise and intensity non-uniformities (INU). This paper presents a new efficient MI-based similarity measure which applies Expectation Maximisation for Principal Component Analysis (EMPCA-MI), to afford significantly lower computational complexity, while providing analogous image registration performance with other feature-based MI solutions. Experimental analysis corroborates both the improved robustness and faster runtimes of EMPCA-MI, for different test datasets containing both INU and noise artefacts.