In silico design control of the trade-off balance in robustness and fragility of logical circuits using DNA nanostructures

The logical computation using a self-assembly process of DNA nanostructures can provide unbreakable cryptosystems or intelligent molecular robots. Focusing on the trade-off problem between the error-free robustness for stability and the error-tolerable fragility for error correction through reconnections, we present in silico analyses and propose adjustments of indirect factors to control the balance between the two. Computer simulations are helpful to characterize target problems and search optimized solutions to improve developing systems. It is expected that our results will contribute to the construction of important platform technologies for reliable DNA applications.