Parallel flow and mass transfer in polymeric ultrasonic microrresonators

In this work new polymeric microdevices acting as multilayer ultrasonic resonators show their capability and versatility as particle tweezing tools for selective separation or particle sorting. Combination of parallel flows with ultrasonic waves perpendicularly applied allows the mass transfer between them. A strategic position of a pressure node in the channel is required to collect the target cells/particles extracted from their host sample. It is strongly influenced by the 3D vibrational behavior of the plastic structure of the chip. Different chip configurations are being currently developed to optimize the device efficiency of separation, varying two spatial parameters: the distance between the channel and the piezoelectric actuator and the channel length (that is, the relationship between length-width of the chip). Several tests are made on each chip varying the frequency about 12% around the central value of 1MHz to analyze the stability of the pressure node established inside the channel.