Mechanobiologic acoustics on bone cellular and in vivo adaptation

It is well documented that ultrasound, as a mechanical signal, can produce a wide variety of biological effects in vitro and in vivo. The purpose of the current study was to evaluate acoustics on both in vivo and in vitro adaptation of bone cells and tissue. The results indicated that focused ultrasound can create local fluid flow nearby cells. In vivo results suggest that low-intensity pulse ultrasound can induced mechanical wave in tissue and initiate bone adaptation. Thus, dynamic ultrasound can inhibit bone loss and preserve bone strength under conditions of estrogen deficient osteopenia.