Effects of Geraniin in Geranium sibiricum L. on antioxidant function of S180 mice

Objective: to investigate effects of Geraniin in Geranium sibiricum L. on antioxidant function of S
₁₈₀
mice. Methods: S
₁₈₀
entity-tumor mice as study model were used to investigate effects of Geraniin on tumor inhibition rate and indices of immune organs of S
₁₈₀
mice; kits were used to determine SOD activity and T-AOC activity in red blood cells and MDA content of red blood cells in the whole blood of S
₁₈₀
mice. Results: Geraniin could significantly inhibit growth of S
₁₈₀
entity-tumor, significantly increase thymus index and spleen index, significantly increase SOD activity and T-AOC activity in red blood cells of S
₁₈₀
mice and significantly reduce MDA content of red blood cells in the whole blood of S
₁₈₀
mice. Conclusion: Geraniin could significantly inhibit the growth of entity-tumors of S
₁₈₀
mice and its effect mechanism was possibly associated with increase of antioxidant function of S
₁₈₀
entity-tumor mice.