Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implant

We introduce a microsensor implant (MSI) comprising microsensors for dissolved oxygen, pH and electrical impedance to monitor ingrowth behavior of biomaterial coatings into tissue. The chorioallantoic membrane (CAM) of ex ovo transferred avian embryos served as a physiological tissue environment. Here, different signal progressions during ingrowth could be observed in a time period of 3-4 days. We tested biodegradable poly(DL-lactide-co-glycolide) and biostable plasma-polymerized coatings compared to an uncoated MSI.