The Effect of Mono- and Di-Methylation of H3K4 on Transcription Might Be Associated with Gene Length

We compared the distribution of methylation of histone H3 lysine 4 on genes of different lengths. The result shows that the mono- and di-methylation present different distribution patterns on genes with different lengths. Furthermore, these two methylations exhibit distinct correlations with expression when gene length is different. Our results suggest that the gene length might play a role in the effect of these two modifications on transcription.