Modeling the Mechanism of HBV Infection

A mathematical model describing the relationship between uninfected hepatocytes, infected hepatocytes, HBV, CD8+ T-cells(CTL), antigen presenting cells, CD4+ T cells (Th
₁
and Th
₂
), plasma cells, antibody, and so on was established to explain the mechanism of HBV infection. The mathematical analysis result shows the condition of how can the immune system eliminate HBV entirely from the body. The model can even simulate the wide variety of clinical manifestations of HBV infection(acute hepatitis, fulminant hepatitis, acute-turn-chronic hepatitis ,chronic hepatitis, recurring hepatitis and asymptomatic hepatitis).