Multifunctional superparamagnetic iron-oxide nanoparticles (SPION) for treating orthopedic and biofilm infections

As with all surgical procedures, implantation comes with the added risk of infection. The inability of antibacterial therapy to treat persistent infection demonstrates the need for a more advanced therapeutic approach. The goal of this proposal is, for the first time, to use superparamagnetic iron oxide nanoparticles (SPION) to treat infection on biomedical devices. The hypothesis of this study is that SPION could be used as a modular tool for comprehensive infection treatment including disease targeting, infection control, and therapy feedback.