Short-term QT variability: A marker for reduced repolarization reserve in anthracyclin therapy

Using Fiducial Sgment Averaging we measured the individual QT intervals in 5 minute recordings of patients on anthracyclin therapy. These intervals are used to calculate the short term QT-variability. The effect of anthracyclin therapy is seen in an increased variability together with an increased QTc interval both signifying a reduced repolarization reserve.