Control and reversal of tumor growth by ultrasound activated microbubbles

It has been known that tumor insonation after intravenous microbubble injection may lead to transient reduction of tumor blood flow. Subsequent experiments showed that repeated induction of tumor blood flow disruption may retard tumor growth. This paper reports an initial investigation of the underlying blood flow disruption phenomena and the first systematic investigation of the control of tumor growth by the combination of moderately intense ultrasound and microbubbles.