Medical image segmentation based on immune clonal optimization

Based on the clonal selection theory of Artificial Immune System, a novel optimal entropy threshold medical image segmentation method is proposed, in which, the affinity function is the optimal entropy threshold, and the medical image segmentation is considered as a optimization problem, clonal operator effectively enlarges searching range, supplies the diversity of solutions and can find the optimal threshold. This paper applies new algorithm to the challenging application: gray matter/white matter segmentation in MRI images, the algorithm is depicted in detail and the convergence is proven, the performance and computational complexity of the algorithm are described by quantitative analysis. Experiment results demonstrate the potential of the algorithm for medical image segmentation.