A configurable IC for wireless real-time in vivo monitoring of chemical and electrical neural activity

A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm
²
IC is fabricated using a 0.5-mum CMOS process and incorporates a 71-muW, 3
^rd
-order, configurable, DeltaSigma modulator per channel, achieving an input-referred noise of 4.69 muV
_rms
in 4-kHz BW and 94.1 pA
_rms
in 5-kHz BW for electrical and fast-scan voltammetric chemical neurosensing, respectively. Brain extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been recorded wirelessly on multiple channels using 300-V/s fast-scan cyclic voltammetry in the anesthetized rat.