Rationale for human modelling in human in the loop systems design

Human modelling in human-in-the-loop systems (HITLS) design can be a complex and dynamic endeavour. Thereby it needs a theoretical framework for grounding methods and models on verified principals and an integrative approach that takes into consideration the specificity of biological organization of living systems, according to the principles of physics, and a coherent way to organize and integrate structural and functional artificial elements. This paper focuses on the rationale of human modelling for HITLS design, in the context of a conceptual framework based on Chauvet's mathematical theory of integrative physiology (MTIP).