Mining Adverse Drug Reactions with E-Science Workflows

In this paper, we describe the challenges faced when conducting large-scale adverse drug reaction (ADR) studies by mining large-scale primary care databases. We provide a high-level view of the design of a generic informatics infrastructure that is needed to address such challenges. We also present our realization of such an infrastructure using a re-usable workflow-based e-Science middleware, and describe our experiences using the system based on studying the risks associated of statin induced myopathy and myalgia from UK-based data sources.