In vivo intravital imaging with a dual-axes confocal microscope in skin

In this paper, a miniaturized intravital dual-axes confocal (DAC) microscope for investigating gene transfer in skin in vivo was reported. In vivo 3-D imaging not only validates what can be observed in ex vivo tissue sections, but gives spatial and temporal information in a living specimen. This opens up new opportunities in advancing disease and treatment research in the skin.