Principal Component Analysis of Infectomes in Human Brain Endothelial Cell after C. neoformans Infection

Cell surface molecule CD44 of human brain microvascular endothelial cells (HBMEC) is the receptor of Cryptococcus neoformans during the infection. We performed microarray analysis and used principle component analysis to examine gene profiles of HBMEC in responses to C neoformans infection. The CD44 levels increases, peaking at the 4-hour time point and then declined gradually. Seventy genes displayed a similar gene profile. Our results showed a dynamic relationship between pathogen-host interactions. The data is useful for the analysis of invasion mechanism of C neoformans into HBMEC.