Esophageal Electric Fields are Correlated to Atrial Defibrillation Thresholds: Towards Patient-Specific Optimization of External Atrial Defibrillation

Studies have investigated the effect of defibrillator paddle position on the efficacy of external electrocardioversion of atrial fibrillation, without agreeing upon an optimal placement. We wish to investigate using esophageal electric fields (EEFs) to predict atrial defibrillation thresholds (ADFTs) on a patient-specific basis. We propose to (1) investigate the relationship between EEFs and ADFTs using computer simulations, (2) develop an esophageal probe that can accurately measure three-dimensional electric fields and (3) investigate the relationship between EEFs and ADFTs values in-vivo. Sixteen anterior-anterior and eleven anterior-posterior placements were simulated yielding a negative relationship between EEFs and ADFTs (R2=0.91 and 0.93, respectively). An esophageal probe was developed that accurately measures EEFs. Animal studies showed a negative relationship between EEFs and ADFTs. This data suggests using EEFs to predict ADFTs on a patient-specific basis is plausible.