3D-OSEM Reconstruction from truncated data in pinhole SPECT

Pinhole SPECT can provide high-resolution image with high sensitivity when a collimator is close to an object. However, truncation causes artifact and decreases quantitative accuracy. Defrise et al proposed new reconstruction theory to prevent overestimation due to truncation. In this paper, we applied Defrise theory to three-dimensional pinhole SPECT reconstruction and validated our implementation by computer simulation.