A Platform for in silico Modeling of Physiological Systems

This paper describes our challenge of developing base systems necessary and useful for a physiome typed platform for physiological modeling and simulation across multiple scales of time and size through diverse hierarchies of living organisms. Our base systems include a CellML compatible standardized description of structure and dynamic equations (rules for time evolution) of biological organisms in general. A database that can deal with the standardized description and APIs for large scale model constructions and their simulations are also considered.