Estimation of Intracellular Potentials from Evoked Neural Pulse Trains

An algorithm is presented for estimating the time course of intracellular generator potentials on the basis of the times of occurrence of evoked neural impulses, under conditions of external sinusoidal stimulation, and assuming SS-IPFM encoding. Recorded neural pulses are applied to the output of a theoretical SS-IPFM encoder (``in reverse'') and a least-squares criterion is adopted for estimating the input sinusoid and its harmonics which would have given rise to the same train of pulses. Illustrative simulation examples of the algorithm are given, and its practical applications are discussed.