Follow-up computerized study of Clozaril therapy

The primary harmful side effect of Clozaril, an antipsychotic agent, is agranulocytosis. An established computerized database was modified and improved to monitor Clozaril patients in New York State Psychiatric Centers. Six centers with a total of 241 patients were monitored from 6/1/1991 to 9/30/1992. White blood cell test results were recorded for each patient. Thirteen patients were found to exhibit signs of agranulocytosis. The pattern of results for each of the 13 patients was examined, indicating that sound courses of action were subsequently taken. Further work is planned to include continued monitoring and age and/or sex based studies.<
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