Experimental design of exit wave reconstruction from a transmission electron microscope defocus series

Recently published methods reconstruct the complex exit wave of the specimen in a transmission electron microscope by combining a number of images recorded at different defocus values. An expression is derived for the variance of the reconstructed wave as a function of the experimental parameters that can be freely chosen. It is shown how these parameters can be used for experimental design, that is, for minimizing the variance of the reconstructed wave.<
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