Computer model of cardiac diastolic dynamics

A dynamic model of diastolic pressure (DP/dt) was derived from basic biophysical principles for use in a systems analysis of circulatory blood flow. In the model, DP/dt is considered to be biphasic in nature and of the general mathematical form DP/dt f(R, Q) where R (ventricular relaxation rate) controls the isovolemic relaxation phase and Q (flow into the ventricle) determines the pressure during the diastolic filling period. When the model is incorporated into a general cardiovascular model it can be used in computer simulation studies to analyze the effects of changes in parameters such as diastolic ventricular compliance and relaxation time on overall circulatory blood flow.<
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