Fixed and Random Effect Analysis of Multi-subject Spatial Activation Maps in Wavelet Domain

A method is proposed for modeling random and fixed effects in statistical maps of multisubject fMRI data. Using this model, we separate a fixed common activation map and a random effect for each subject. The proposed model shows a good multisubject activation detection for group analysis and also illustrate that the between subject variation lies mostly in activated areas. The method was implemented and tested on both simulated and experimental functional MRI data of 9 subjects.