Improved magnetoencephalography source reconstruction considering anatomical connectivity of cortical sources

In this paper, an improved magnetoencephalography (MEG) source reconstruction technique considering anatomical connectivity of cortical sources is proposed. The anatomical connectivity information was taken into account by calculating three-dimensional geodesic distance between neighboring sources, and then the resultant inverse solutions were compared with those of other cases:1)Inverse estimate without connectivity information; 2)Use of Euclidean distance instead of geodesic distance. The proposed technique was applied to realistic simulations for a real brain anatomy, and the results showed that estimated sources can be smoother and more accurate by using the anatomical connectivity information.