High resolution PET imaging characteristics of /sup 68/Ga, /sup 124/I and /sup 89/Zr compared to /sup 18/F

In this study the imaging characteristics influencing the quantitative accuracy of /sup 68/Ga, /sup 124/I and /sup 89/Zr were determined and compared to those of /sup 18/F using a 3D high resolution PET (high resolution research tomograph, HRRT) scanner. Although there were large discrepancies found in the sensitivity of these isotopes, which can be explained by their positron abundancy, none of the assessed imaging characteristic prevents the isotopes for usage in (high resolution) quantitative PET imaging. Care has to be taken, however, that accurate correction methods are used for dead time, background and scatter, and partial volume.