Self-assembling DNA tiles - mechanisms of error suppression

Self-assembling DNA tile is an important method of molecular computation. In this method, DNA tiles self-assemble a large two-dimensional lattice by the specific hybridization between complementary strands. Hence hybridization is a stochastic process, it is difficult to obtain an aggregate with no error. Growth speed of the aggregate must be very low to obtain an aggregate that contains less error. This paper presents a novel method called layered tile model (LTM) to realize the reliable self-assembly of DNA tiles.