Maximum-likelihood expectation-maximization algorithm for improved clinical SPECT scintimammography

Conventional MLEM and OSEM algorithms used in SPECT Tc-99m sestamibi scintimammography produce hot spot artifacts (HSA). We investigated a suitable modification of MLEM and OSEM algorithms needed to reduce HSA. Patients with suspicious breast lesions were administered 10 mCi of Tc-99m sestamibi and SPECT scans with patients in prone position with uncompressed breasts were acquired. In addition, to simulate breast lesions, some patients were imaged with a number of breast skin markers each containing 1 /spl mu/Ci of Tc-99m. We modified MLEM and OSEM algorithms by removing from the backprojection step the rays that traverse the periphery of the support region on the way to a detector bin when their path length trough this region is shorter than some preset critical length. Such very short paths result in a very low projection counts contributed to the detector bin and this in turn gives rise to a overestimation of the activity in the peripheral voxels in the backprojection step, thus creating HSA. We analyzed the breast-lesion contrast and suppression of HSA in the images reconstructed using conventional and modified MLEM and OSEM algorithms vs. critical path length (CPL). For CPL/spl ges/0.01 pixel size, we observed improved breast-lesion contrast and lower noise in the images reconstructed, and a very significant reduction of HSA in the maximum intensity projection (MIP) images.