CMOS sensor array for electrical imaging of neuronal activity

A CMOS sensor array for extracellular, high density imaging of electrical activity of living neural networks is presented. The chip is fabricated in an extended 0.5 /spl mu/m CMOS technology, and provides 128 /spl times/ 128 pixels with a pitch of 7.8 pm; full frame rate is 2000 frames per second. Dynamic maps from single cells and cultured networks are shown.