On-chip microdialysis system with in-line sensing capabilities

An on-chip microdialysis system with in-line sensing electrodes is presented here. The design of this system is based on membrane bonding onto microfluidic channels, having a high surface to volume ratio to promote efficient dialysis and in-situ integration with biosensors. Miniaturization of the microdialysis technique has several advantages including higher recovery of analytes, better estimation of local analyte concentration, and less invasive systems when used for continuous monitoring. The permeability of this system to glucose has been determined to be 2.5280 /spl mu/m/s (std: 0.3723 /spl mu/m/s) and 3.5543 /spl mu/m/s to small salt ions.