A low noise full customized 32-channel CMOS biopotential sensor chip for extracellular neural signal recording

In this paper we present the design and testing of a 32-channel full-customized CMOS biopotential sensor integrated circuit for sensing the propagation of action potentials in single nerve cell. The chip provides a satisfactory signal-to-noise ratio for neural signals with amplitudes in the range of 50-500 /spl mu/V and frequency spectrum in the range of 20-2000 Hz. The prototype IC was fabricated by MOSIS using AMI's 1.5 /spl mu/m, double poly, double level metal CMOS technology.