The resonance frequency of SonoVue/spl trade/ as observed by high-speed optical imaging

The resonance frequencies of individual SonoVue/spl trade/ contrast agent bubbles were measured optically by recording the radius-time curves of a single microbubble at 24 different frequencies. For these experiments, the Brandaris 128 fast framing camera was operated in a special segmented mode. The resonance frequencies found for SonoVue/spl trade/ microbubbles are in good agreement with the modified Herring model for coated bubbles indicating that the shell only slightly affects the resonance frequency of this class of contrast bubbles.