Photon migration in a three-dimension human brain model: Monte Carlo simulation

In this paper, we demonstrate the time-resolved photon migration phenomena in a 3-D human brain model at variable wavelengths with Monte Carlo simulations. In our simulations, the brain model consists of five layers: scalp, skull, cerebrospinal fluid, gray matter, and white matter. The model imitates the geometry of a real human brain obtained from MRI images. Our simulations can reveal the intensities of photons reaching different layers. We can optimize the source-detector separation in experiments by analyzing the partial intensity variation of the different layers in the brain model.