Design of an integrated potentiostat circuit for CMOS bio sensor chips

A design strategy is presented for potentiostat circuits suitable for electronic bio sensors on CMOS. Guidelines are given to guarantee stable operation under the condition of widely varying and only roughly known electrochemical parameters. A concrete design example used in a fully electronic DNA sensor array CMOS chip is shown. Measurement results with a biological analyte applied to that chip prove proper operation of the potentiostat.