Multimodal Ultrasound Fusion of Biomechanical and Microvascular Parameters to Enhance Malignancy Classification of Breast Tumors

The diagnosis of breast tumors presents a major clinical challenge, frequently resulting in unnecessary biopsies owing to the common imaging features of benign and malignant lesions. This study proposes a non-invasive multimodal ultrasound approach that integrates Sound Touch Viscoelasticity Imaging and Ultra-Micro Angiography to enhance diagnostic precision. Analysis of 107 biopsy-proven tumors showed that the multimodal fusion significantly improved accuracy to an AUC of 0.90, outperforming single methods. These results indicate that the combination of quantitative biomechanical and microvascular features provides more comprehensive tumor assessment, potentially reducing false positives and unnecessary biopsies.