Integrated Ultrasound, Functional Ultrasound, and Photoacoustic Tomography for Multimodal Human Imaging

In this paper, we present a semi-ring transducer based multimodal tomography platform integrating ultrasound tomography, ultrafast-ultrasound tomography, and multispectral photoacoustic tomography in a 256-element, 70 mm radius array. Using integrated imaging acquisition sequence, the system captures structural, hemodynamic, and molecular contrasts simultaneously with B-mode compounded frame rate up to 400 frames per second. The system is validated against a blood-flow mimicking phantom and demonstrates sub-500 µm resolution and blood imaging sensitivity. In vivo human finger imaging show co-registered ultrasound anatomy, photoacoustic vascular maps, functional ultrasound flow images, and multispectral oxygenation mapping. Overall, this platform offers a powerful tomographic tool for comprehensive vascular diagnostics and functional assessment in both research and clinical settings.