Cold Atmospheric Plasma for Burn Healing in Mice

Cold atmospheric plasma (CAP) is a promising treatment for burns due to its antibacterial properties, ability to promote wound healing, and inhibition of scarring. However, before its clinical transformation, two major challenges need to be addressed: potential harmful effects on human skin under long exposure time, and the high flow rate of gas, causing wound dryness and hindering healing. To tackle these issues, we conducted an exploratory study using a mouse burn model to investigate the impact of CAP parameters on burn healing. Specifically, we examined the exposure time, course of CAP treatment, velocity of flow, frequency, and carrier gases. Through our research, we were able to preliminarily explore the mechanism of CAP’s impact on burn repair. Our findings provide an essential theory for the safe and effective clinical application of CAP in burn treatment. Furthermore, this work has practical significance for advancing research into new treatment methods for burns. Overall, our study contributes valuable insights into the field of CAP application, paving the way for future studies focused on optimizing CAP treatment protocols for burn injuries.