A Smart Wearable System for Tumor Monitoring and Adaptative Drug Delivery

This paper presents a wearable, non-invasive smart drug delivery system that integrates real-time tumor monitoring and adaptive chemotherapy. Designed for subcutaneous tumor tracking and dynamic drug infusion, the system continuously monitors tumor volume, while $\mathbf{p H}$ sensitive, fluorescent doxorubicin (DOX)-loaded nanoparticles enable blood drug concentration analysis to determine optimal dosing. A Nonlinear Model Predictive Control (NMPC) algorithm based on pharmacokinetic-pharmacodynamic (PKPD) scheme dynamically adjusts drug release to determine adequate dosing, thereby preventing toxicity and drug resistance. Hence, the proposed system incorporates tumor strain sensing and spectroscopic drug monitoring to regulate doxorubicin delivery through a closed-loop MPC framework. A cost analysis is also provided to assess the feasibility of largescale implementation