Establishment point-of-care device for real-time detection creatinine of acute ischemic stroke patients

Cerebrovascular diseases rank as the third leading cause of death, following cancer and heart disease, according to the World Health Organization (WHO) [1]. Stroke-related mortality remains difficult to control, with one person dying from a stroke every three minutes on average [2]. This challenge arises because strokes occur suddenly, depriving the brain of oxygen. In acute ischemic stroke, the condition is often unstable, and brain tissue deterioration continues even after hospitalization. Therefore, early diagnosis and timely, appropriate treatment during the critical window before deterioration are essential to reducing stroke-related mortality [3]–[6]. Clinical data indicate that a BUN/Creatinine ratio greater than 15 is a key indicator for stroke risk assessment [7]. However, current hospital and home care practices fail to implement effective real-time monitoring. This is primarily due to hospitals relying on large central laboratory analyzers to measure BUN and Creatinine concentrations, making immediate BUN/Creatinine ratio assessments unavailable. To address this issue, a point-of-care creatinine detection device was designed to assess acute stroke deterioration. The developed system measures BUN/Creatinine levels in blood or bodily fluids and provides a critical golden window for timely intervention when acute dehydration occurs (BUN/Creatinine > 15). The device was developed as a feasible diagnostic system using commercially available test strips that meet clinical and regulatory standards. A portable prototype was created to detect blood creatinine concentrations within 10 minutes of sampling, allowing healthcare workers or caregivers to make timely evaluations and treatment decisions. By enabling continuous creatinine monitoring, the device helps reduce the risk of stroke progression.