Classifying the DNA sequence using Optimized Naive Bayes Approach: A Comparative Analysis of Machine Learning Algorithms

In bioinformatics, the exact classification of DNA sequences is essential to increasing comprehension of genetic structures and functionalities. This research introduces an enhanced Naive Bayes approach (ENB) specifically designed to handle more complexities related to DNA sequence data. This research integrates advanced feature weighting and optimized probability estimation techniques to enhance classification accuracy substantially. The proposed work demonstrated superior efficacy to traditional ML algorithms like Random Forest, SVM, Decision-Trees, K-Nearest Neighbors, Gradient Boosting etc. The proposed method attained a level of accuracy of 98%, and proposed approach performs better than the other models, with 94% accuracy in Logistic Regression coming in second.