A Modified Ultra-Flexible Neural Electrode for Long-Term Dual-Modality Detection Across Multiple Brain Regions

We present a novel modification for an ultra-flexible neural probe capable of simultaneous electrophysiological recording and dopamine detection within cerebral tissue. Following electrode modification, the electrochemical stability of the electrode coating was enhanced, and its specific surface area was increased, thereby significantly improving its sensitivity to dopamine. Building upon this foundation, the ultra-flexible design minimizes damage to brain tissue, enabling stable simultaneous detection of electrophysiological and electrochemical signals for over six weeks. The high-density electrode array design facilitates concurrent monitoring of activities across multiple brain regions. This novel approach provides new methodologies for neuroscience research and the treatment of brain disorders.