Benzydamine-Loaded Casein Nanospheres Embedded in Polyelectrolyte Multilayers

Polyelectrolyte multilayers (PEMs) films containing benzydamine hydrochloride (Benz)-loaded casein nanoparticles are developed aiming to increase the structure drug loading efficiency and to prolong the drug release. The multilayers are built on biodegradable polyester substrates, which are previously charged in a corona discharge. Medium viscosity sodium alginate (SA) is used as a partner in the multilayer formulation. The SA and the casein nanoparticles are deposited on the substrate using the layer-by-layer (LbL) deposition technique. The drug loading efficiency and the release kinetics in artificial saliva are determined spectrophotometrically.