A High Quality and Minimal Invasive Interventional Brain Machine Interface System Based on Neural Spiking Activities

Intracranial neural electrodes have significantly contributed to research and clinical treatment, and recent endovascular neural interfaces offer minimally invasive approaches. However, these pioneering studies demonstrate the safety, but unable to resolve single-unit activity in large animal models or human patients, impeding a broader application as neural interfaces in clinical practice. We introduce an ultraflexible microelectrode array capable of multi-channel single-unit recording in large animals with minimal invasiveness through a novel interventional implantation strategy.