Infrared Spectroscopy Imaging of Cardiac Atria From Mice Treated with Interleukin-1beta: A Preliminary Clustering Analysis

This study explores the application of Fourier-transform infrared (FTIR) spectroscopy imaging to analyze changes in the cardiac atria of mice treated with interleukin-1 beta (IL-1beta), a cytokine known to influence cardiac remodeling. By employing k-means clustering on the spectral data, we identified distinct clusters that differentiate between IL-1beta-treated tissues and controls. The analysis revealed significant spectral differences, particularly in the amide band region, which suggests variations in protein content. These preliminary findings will be expanded into a more thorough investigation of the composition of IL-1beta-treated tissues.