A Compact Dead-Zone-Free Multi-Channel Stimulation and Recording System for Precision Peripheral Nerve Modulation

Peripheral nerve modulation has a certain potential in motor recovery, but the majority of systems suffer from the drawback of dead time caused by switching channels to achieve multi-channel stimulation. As a response to this challenge, we have developed a peripheral nerve modulation device with 64-channel recording and 16-channel stimulation without dead time. Through modulation of the rat sciatic nerve, we identified the crucial role of initial phase and amplitude in the outcomes of dual-channel combined stimulation. This design not only enhanced neural activation capabilities with constant power supply but also achieves more precise neural activation and reduces unintentional activation.