Microfluidic Biosensors Based on Dual-Layer Metasurfaces

Metasurface plays an important role in optical applications, and biomolecular sensing based on metasurface has a wide application prospect in the medical field, and the combination of metasurface biosensors and microfluidic has also attracted wide attention. Some existing studies on microfluidic metasurface biosensors focus on single-layer metasurface biosensing detection; in this study, we propose a dual-layer microfluidic channel-based terahertz (THz) biosensor based on metal metasurfaces, which combines microfluidic technology to place analytes in microfluidic channels between resonant structures to achieve real-time sensing detection of analytes. The simulation results show that the analytes vary from 1.0 to 2.0 refractive index, and the sensitivity of the biosensor’s resonance point can reach 248.29 GHz/RIU. This dual-layer microfluidic THz biosensor provides a new method to improve sensor sensitivity, which has potential application value in the biomedical field.