Power of Multi-Modality Variables in Predicting Parkinson's Disease Progression

Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The increasing demand for high-accuracy forecasts of disease progression has led to a surge in research employing multi-modality variables for prediction. In this review, we selected articles published from 2016 through June 2024, adhering strictly to our exclusion-inclusion criteria. These articles employed a minimum of two types of variables, including clinical, genetic, biomarker, and neuroimaging modalities. We conducted a comprehensive review and discussion on the application of multi-modality approaches in predicting PD progression. The predictive mechanisms, advantages, and shortcomings of relevant key modalities in predicting PD progression are discussed in the paper. The findings suggest that integrating multiple modalities resulted in more accurate predictions compared to those of fewer modalities in similar conditions. Furthermore, we identified some limitations in the existing field. Future studies that harness advancements in multi-modality variables and machine learning algorithms can mitigate these limitations and enhance predictive accuracy in PD progression.