A Miniature pH Sensor in a Subcutaneous Injection Needle for Biofluid Sensing | IEEE Journals & Magazine | IEEE Xplore

A Miniature pH Sensor in a Subcutaneous Injection Needle for Biofluid Sensing


Abstract:

The pH value in bodily fluids is a crucial diagnostic marker. Conventional glass-rod pH sensors display reliability in aqueous solutions, but the pH-sensitive glass membr...Show More

Abstract:

The pH value in bodily fluids is a crucial diagnostic marker. Conventional glass-rod pH sensors display reliability in aqueous solutions, but the pH-sensitive glass membrane makes them prone to inaccuracies in viscous solutions due to elevated junction potentials and bulky design hinders miniaturization. To overcome this issue, this work introduces a new pH sensor design and fabrication that enables miniaturization and reliability in aqueous and viscous solutions and facilitates insertion into a needle for in vivo monitoring. Utilizing a printing technique for the application of iridium oxide (IrOx) and silver/silver chloride coating on a single flexible polyimide substrate offers cost-effectiveness and production scalability. The sensor then is tailored with a sharp blade to a narrow strip that fits into a 20-gauge needle. The electrochemical measurements demonstrate that electrodes produced through this method demonstrate an accuracy of up to 0.1 pH within a narrow pH range (7.35–7.45) in buffer solutions and real human serum tests.
Published in: IEEE Sensors Letters ( Volume: 8, Issue: 10, October 2024)
Article Sequence Number: 1502504
Date of Publication: 04 September 2024
Electronic ISSN: 2475-1472

References

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