Naringin abrogates acrylamide–induced renal dysfunction by modulating biochemical and histological alterations in rats

Acrylamide (ACR) is a by-product of food that is formed as a result of frying or grilling, making crackers, bread, and roasting coffee. It has been linked to a number of negative effects, one of which is renal damage. This research evaluated the nephroprotective effects of naringin (NAR) against ACR-induced renal damage in rats. Nephrotoxicity was induced with ACR (40mg/kg b.w., p.o.) and thereafter treated with NAR (50 and 100 mg/kg b.w., p.o.) for 14 consecutive days. ACR intoxication altered biochemical parameters that are associated with the functionality of the kidney. NAR abrogated acrylamide-induced renal damage by significantly decreasing serum urea and creatinine levels. NAR treatment caused a significant increase in glutathione, superoxide dismutase, catalase and glutathione peroxidase activities and reduced malondialdehyde levels in kidney tissues. The histopathological examinations showed that acrylamide altered the histopathological architecture of the kidney tissues, which was reversed by the administration of NAR. These data showed the protective efficacy of NAR against acrylamide-induced renal toxicity by improving antioxidant status, functional alterations and histopathological changes.